Glia and Neuroinflammation

We study the pathology of brain disorders
and the mechanisms of acupuncture based on the gliocentric view.

Our new paper is published in Cell Reports!

Diaschisis after stroke through astrocytic GABA

Excessive Astrocytic GABA Causes Cortical Hypometabolism and Impedes Functional Recovery after Subcortical Stroke

Research


Reactive astrocytes in brain disorders

We study the pathological role of reactive astrocytes in various brain disorders.

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Glia-Immune interaction

We study the interaction between glia and meningeal immunity.

Korean Medicine

We study the molecular, cellular and circuitry neurobiology of acupuncture and herbal medicine based on the gliocentric view.

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Wake up dormant dopaminergic neurons to reverse Parkinson’s disease!

Astrocytic GABA identified as the novel therapeutic target of motor symptoms in Parkinson’s disease

Publications


[Pre-prints]

  1.  Nam MH*, Park JH*, Song HJ, Choi JW, Kim S, Jang BK, Yoon HH, Heo JY, Cho DW, Yang YS, Han SC, Kim SW, Oh SJ, Jeon SR, Park KD#, Lee CJ#, KDS2010, a newly developed reversible MAO-B inhibitor, as an effective therapeutic candidate for Parkinson’s disease, BioRxiv, 2020, doi: https://doi.org/10.1101/2020.07.06.190579 


[2020]

  1. Nam MH*, Won W*, Han KS, Lee CJ#, Signaling mechanisms of μ-opioid receptor (MOR) in the hippocampus: disinhibition versus astrocytic glutamate regulation, Cellular and Molecular Life Sciences, 2020.
  2. Nam MH*, Cho J*, Kwon DH, Park JY, Woo J, Lee J, Lee S, Ko HY, Won W, Kim RG, Song H, Oh SJ, Choi JW, Park KD, Park EK, Jung H, Kim HS, Lee MC, Yun M, Lee CJ#, Kim HI#, Excessive astrocytic GABA causes cortical hypometabolism and impedes functional recovery following subcortical stroke, Cell Reports, 2020, 32, 107861.
  3. Yoon HH*, Nam MH*, Choi I, Min J, Jeon SR#, Optogenetic inactivation of the entopeduncular nucleus improves forelimb akinesia in a Parkinson's disease model. Behavioural Brain Research, 2020, 10:112551.
  4. Heo JY*, Nam MH*, Yoon HH, Kim J, Hwang YJ, Won W, Woo DH, Lee JA, Park HJ, Jo S, Lee MJ, Kim S, Shim JE, Jang DP, Kim KI, Huh SH, Jeong JY, Kowall NW, Lee J, Im H, Park JH, Jang BK, Park KD, Lee HJ, Shin H, Cho IJ, Hwang EM, Kim Y, Kim HY, Oh SJ, Lee SE, Paek SH, Yoon JH, Jin BK, Kweon GR, Shim I, Hwang O, Ryu H#, Jeon SR#, Lee CJ#, Aberrant tonic inhibition of dopaminergic neuronal activity causes motor symptoms in animal models of Parkinson’s disease, Current Biology, 2020;30(2):276-291.
  5. Pandit S, Neupane C, Woo J, Sharma R, Nam MH, Lee GS, Yi MH, Shin N, Kim DW, Cho H, Jeon BH, Kim HW, Lee CJ#, Park JB#, Bestrophin1-mediated tonic GABA release from reactive astrocytes prevents the development of seizure-prone network in kainate-injected hippocampi, Glia, 2020;68(5):1065-1080


[2019]

  1. Nam MH*, Han KS*, Lee J*, Won WJ, Koh W, Bae JY, Woo J, Kim J, Kwong E, Choi TY, Chun H, Kim SB, Park KD, Choi SY, Bae YC#, Lee CJ#, Activation of astrocytic mu-opioid receptor causes conditioned place preference, Cell reports, 2019;28(5):1154-1166.
  2. Park JH*, Ju YH*, Choi JW, Song HJ, Jang BK, Woo J, Chun H, Kim HJ, Shin SJ, Yarishkin O, Jo S, Park M, Yeon SK, Kim S, Kim J, Nam MH, Londhe AM, Hwang SY, Kim SW, Cho J, Pae AN, Lee CJ#, Park KD#, Newly developed reversible MAO-B inhibitor circumvents the shortcomings of irreversible inhibitors in Alzheimer's disease. Science Advances, 2019;20:5(3):eaav0316.


[2018]

  1. Woo DH*, Bae JY*, Nam MH*, An H, Ju YH, Won J, Choi JH, Hwang E, Han KS, Bae YC#, Lee CJ#, Activation of Astrocytic m-opioid Receptor Elicits Fast Glutamate Release Through TREK-1-Containing K2P Channel in Hippocampal Astrocytes, Frontiers in Cellular Neuroscience, 2018;12:319.
  2. Nam MH*, Han KS*, Lee J, Bae JY, An H, Park S, Oh SJ, Kim E, Hwang E, Bae YC#, Lee CJ#, Expression of μ-Opioid Receptor in CA1 Hippocampal Astrocytes, Experimental Neurobiology, 2018;27:120-128.


[2017]

  1. Nam MH*, Park M*, Park H, Kim Y, Yoon S, Sawant VS, Choi JW, Park JH, Park KD, Min SJ, Lee CJ, Choo H#, Indole-substituted benzothiazoles and benzoxazoles as selective and reversible MAO-B inhibitors for treatment of Parkinson’s disease, ACS Chemical Neuroscience, 2017 Mar 23, DOI: 10.1021/acschemneuro.7b00050


[-2017]

  1. Kim BI, Kim JH, Sim DY, Nam MH, Jung JH, Shim B, Lee J, Kim SH, Inhibition of JAK2/STAT3 and activation of caspase‑9/3 are involved in KYS05090S‑induced apoptosis in ovarian cancer cells. International Journal of Oncology, 2019;55(1):203-210.
  2. Paik SH*, Nam MH*, Lee BC#, Cucumis Melo L. alleviates obesity and insulin resistance in obese human subjects and high fat diet-induced obese mice, International Journal of Clinical and Experimental Medicine, 2018;11(6):5774-5783.
  3. Lee SW*, Nam MH*, Lee BC#, Herbal Acupuncture for Type 2 Diabetes: A Systematic Review, Experimental and Therapeutic Medicine, 2017, DOI: 10.3892/etm.2017.4379
  4. Kim JH, Kwon HY, Ryu DH, Nam MH, Shim BS, Kim JH, Lee JY, Kim SH#, Inhibition of CUG-binding protein 1 and activation of caspases are critically involved in piperazine derivative BK10007S induced apoptosis in hepatocellular carcinoma cells, Plos One, 2017;16;12(10):e0186490.
  5. Hong SH, Lee H, Lee HJ, Kim B, Nam MH, Shim BS, Kim SH#, Ethanol Extract of Pinus koraiensis Leaf Ameliorates Alcoholic Fatty Liver via the Activation of LKB1-AMPK Signaling In Vitro and In Vivo., Phytotherapy Research, 2017 Mar 16. doi: 10.1002/ptr.5801.
  6. Nam MH, Jung SJ, Lim J#, Seo E, Lim J, Lee SJ, Yoon SZ, Soh KS#, A novel fibrous duct structure in the brain meninges discovered using polarized light microscopy, Journal of Korean Physical Society, 2016;68(10):1246-53.
  7. Nam MH*, Lee SW*, Na HY, Yoo JH, Paik SH, Ahn KS, Ahn YM, Ahn SY, Choi SH, Lee BC#, Herbal Acupuncture for the Treatment of Obesity, Journal of Acupuncture & Meridian Studies, 2016, 9(2):49-57.
  8. Nam MH, Ahn KS, Choi SH#. Acupuncture: A potent tool for inducing adult neurogenesis, Neural Regeneration Research, 2015;10(1):33-35.
  9. Kim J#, Stefanov M, Nam MH, Kim S, Tracing Mercox Injected at Acupuncture Points under the Protocol of Partial Body Macerations in Mice, Journal of Acupuncture & Meridian Studies, 2015;8(6):314-20.
  10. Nam MH*, Baek M*, Lim J, Lee S, Yoon J, Kim J, Lee MS, Soh KS#. Discovery of a novel fibrous tissue in the spinal pia mater by polarized light microscopy, Connective Tissue Research, 2014;55(2):147–155.
  11. Nam MH, Ahn KS, Choi SH#. Acupuncture stimulation induces neurogenesis in adult brain, International Review of Neurobiology, 2013;111:67-90.
  12. Stefanov M#, Potroz M, Kim J, Lim J, Cha R, Nam MH. The Primo Vascular System as a New Anatomical System, Journal of Acupuncture & Meridian Studies, 2013;6(6):331-338.
  13. SJ Jung, KH Bae, Nam MH, HM Kwon, YK Song, KS Soh#, Primo Vascular System Floating in Lymph Ducts of Rats, Journal of Acupuncture & Meridian Studies, 2013;6(6):306-318. (Featured article)
  14. Lee SH, Bae KH, Kim GO, Nam MH, Choi YB, Kwon HM, Ryu Y, Soh KS#. Primo vascular system in the lymph vessel from the inguinal to the axillary nodes, Evidence-Based Complementary and Alternative Medicine, vol. 2013, Article ID 472704, 6 pages, 2013. doi:10.1155/2013/472704.
  15. Bae KH, Park SH, Lee BC, Nam MH, Yoon JW, Kwon HM, Yoon SZ#. Novel threadlike structures may be present on the large animal organ surface: evidence in swine model, Evidence-Based Complementary and Alternative Medicine, vol. 2013, Article ID 758763, 5 pages, 2013. doi:10.1155/2013/758763.
  16. Stefanov M#, Kim JD, Nam MH, Soh KS. New approach of corrosion casting using direct injection of mercox into the parenchyma of different organs, The Anatomical Record, 2013;296:724–725.
  17. Nam MH, Lim J, Choi SH, Kim SC, Soh KS#. A primo vascular system underneath the superior sagittal sinus in the brain of a rabbit, Journal of Acupuncture & Meridian Studies, 2012;5(5):210-217.
  18. Nam MH, Choi SH, Soh KS#. Light and primo vascular system in the brain, Journal of the Korean Physical Society, 2012;60(6):903-906.
  19. Nam MH, Yin CS, Choi SH, Soh KS#. Adult neurogenesis and acupuncture stimulation at ST36, Journal of Acupuncture & Meridian Studies, 2011;4(3):153-158.
  20. Nam MH, Kim Y, Kim H, Park J, Yeh HY, Lee YS, Lee S, Jung WM, Hong YK, Lee H, Park HJ, Chae Y#, A Comparison Study of Factors of Willingness to Use Traditional Medicine between Korean, Chinese and Taiwanese, J Korean Oriental Med 2011;32(1):36-55.
  21. Kim SY, Kim H, Nam MH, Li Y, Chung HC, Park HJ, Lee H, Chae Y#, Evaluation of a Traditional Korean Medicine Content Factor and Satisfaction with the Drama ‘Daejanggeum’, The Journal of Korean Acupuncture & Moxibustion Society, 2010;27(1):11-20.

Lab people


Min-Ho Nam, KMD, PhD

Principal Investigator

Senior Research Scientist at Center for Neuroscience, Brain Science Institute, Korea Institute of Science and Technology (KIST)

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Post-docs

The NAM Lab always welcomes highly self-motivated Ph.D.s to build up interesting stories of glia and neuroinflammation! Please e-mail me (dr.namminho@kist.re.kr) with your CV (and a cover letter which includes what you have done in the past and what you want to get from the NAM lab).

Graduate Students

The NAM Lab always welcomes highly self-motivated students to discover their talents! Please e-mail me (dr.namminho@kist.re.kr) and we can make a time to meet.

Joo-Yeon Park

Research intern

A talented trainee for the 4th industrial revolution selected by National Research Council of Science and Technology

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Join


Join

The NAM Lab employs a multi-disciplinary approach including optogenetic (chemogenetic), ex vivo electrophysiological, pharmacological and imaging techniques to find mechanistic explanations for how reactive astrocytes contribute to brain pathophysiology and/or how acupuncture works through neuro- and glio-modulation.

Graduate students

The NAM Lab always welcomes highly self-motivated students to discover their talents! Please e-mail me (dr.namminho@kist.re.kr) and we can make a time to meet.

Post-docs

The NAM Lab always welcomes highly self-motivated Ph.D.s to build up interesting stories of glia and neuroinflammation! Please e-mail me (dr.namminho@kist.re.kr) with your CV (and a cover letter which includes what you have done in the past and what you want to get from the NAM lab).

News


Kick-off

NAM lab has been kicked off.

Mar 02, 2020

Teacher's day

Oh lab students expressed their gratitude to me on the Teacher's day, in addition to Dr. Oh. Thank you!

Learn MoreMay 15, 2020

Our lab has been renovated

We are sharing the lab space and facilities with Dr. Soo-Jin Oh's lab. Our lab has been renovated!

May 22, 2020

A new paper is published in Behav Brain Res

Yoon HH*, Nam MH*, Choi I, Min J, Jeon SR. Optogenetic inactivation of the entopeduncular nucleus improves forelimb akinesia in a Parkinson's disease model. Behav Brain Res. (2020) 27;386:112551.

Learn MoreMay 27, 2020

Joo-Yeon has joined our lab as an intern.

Welcome!

May 25, 2020

A new paper has been accepted from Cell Reports!!!

Nam et al. (2020), Excessive astrocytic GABA causes cortical hypometabolism and impedes functional recovery following subcortical stroke, Cell Reports

Jun 13, 2020

News release!!

https://www.eurekalert.org/pub_releases/2020-07/ifbs-ant070720.php https://biz.chosun.com/site/data/html_dir/2020/07/07/2020070703074.html?utm_source=naver&utm_medium=original&utm_campaign=biz

Learn MoreJul 07, 2020

A review paper is accepted from Cellular and Molecular Life Sciences!!

Signaling mechanisms of μ-opioid receptor (MOR) in the hippocampus: disinhibition versus astrocytic glutamate regulation Min-Ho Nam#, Woojin Won#, Kyung-Seok Han, and C. Justin Lee*

Learn MoreJul 08, 2020